Kaguta, Munawar Mauled2020-05-282020-05-282005Kaguta, M.M (2005) Comparison between vaginal misoprostol and intravenous oxytocin in induction of labor at Muhimbili national hospital, Dar es Salaam, Tanzania, Master dissertation, University of Dar es Salaam. Dar es Salaam.http://41.86.178.5:8080/xmlui/handle/123456789/11624Available in print form, East Africana Collection, Dr. Wilbert Chagula Library, Class mark (THS EAF RG736.T34K3)Objective: To compare the safety, efficacy and cost effectiveness of vaginal misoprostol and intravenous oxytocin in induction of labor. Design: Randomized trial. Setting: Labor ward at Muhimbili National Hospital (MNH), Dar es Salaam Tanzania. Methods: One hundred and forty two non-grandmultiparous (< gravida 4) women with indication for labor induction were randomly selected for vaginal misoprostol and intravenous oxytocin methods of induction of labor. Misoprostol was administered to 71 women at a dose of 25|xg four hourly, not exceeding 4 doses, whereas oxytocin infusion was titrated based on patient response. Main outcome measures: The main parameters measured were: induction -to- delivery interval, time from induction to onset of contraction, maternal and fetal outcomes, safety and the cost of induction between the two drugs. Results: The median induction -delivery interval was significantly shorter in the misoprostol group as compared to the oxytocin group (10.86 versus 15.45 hours, p<0.001). The time from induction to beginning of contraction was also significantly shorter in the misoprostol group than in the oxytocin group (2.59 versus 3.57 hours p<0.0015). There was no difference in fetal and maternal morbidity between the groups. There was no single case of uterine rupture. Majority of women in the misoprostol group (70%), required less than 0.2 USD for successful induction, whereas in the oxytocin group 77% spent >2.10 USD for induction. Misoprostol was significantly cheaper (p<0.05). Conclusion: Misoprostol at a dose of 25 jig is safe, effective and cheaper than oxytocin for induction of labor.enVaginal misoprostolIntravenous oxytocinInduction of laborThesis