Mosquitocidal and antimicrobial nor-halimanoids, ent-clerodanoids and other metabolites from some Tanzanian tessmannia and annonaceae species.

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dc.contributor.authorkihampa, Charles
dc.date.accessioned2019-12-09T09:46:51Z
dc.date.accessioned2020-01-07T15:46:23Z
dc.date.available2019-12-09T09:46:51Z
dc.date.available2020-01-07T15:46:23Z
dc.date.issued2008
dc.descriptionAvailable in print form, East Africana Collection, Dr. Wilbert Chagula Library, Class mark (THS EAF QK495.A6K53)en_US
dc.description.abstractThis Thesis reports results from chemical investigations and parricidal, mosquitocidal, mosquito repellent and antimicrobial activity of 16 Tanzanian plant species of the families Leguminosae, Annonaceae, Eurphorbiaceae and Meliaceae, and constituents of some of theplant species. Three Tessmannia species T dens flora, T martiniana var pauloi and T martiniana varmartiniana that are reported to occur only in Tanzania, yielded series of nor-halimanoid and ent-clerodanoid diterpenes, some exhibiting mosquitocidal and antimicrobial activities, while others such as the nor-halimanoids tessmannic acid and its methyl, 2- methylpropyl and 1-methylbutyl esters and the ent-clerodanoids cis-kolavenolic acid, ent-( 1 8-hydroxycarbony1)-cleroda-3, 1 3 (E)-dien- 1 5-oate, (9-epi)-ent-(1 8- hydroxyc arbony1)-cleroda-3 , 1 3 (E)-dien- 1 5 -oate as well as the isocoumarin chlotessmin, are novel natural products, and so are 0-(3-hydroxy-4- hydroxycarbony1-5-pentylpheny1)-3-chloro-4-methoxy-5-pentyl-2-oxybenzoic acid and 5-penty1-3-methoxy-N-butylaniline. Several other mosquitocidal and antimicrobial compounds were obtained from the Annonaceae species Uvaria lungonyana, Uvariodendron pycnophyllum, Polyalthia tanganyikensis and Annona squamosa, among them the aromadendrane sesquiterpenoid tanganyikenol and theosa, kaurane diterpenoid 1 7-acetoxy-ent-kauran- 1 9-al obtained from P. tanganyikensis and A. squamosa respectively, are being reported for the first time. Structural determination of all the isolated compounds was achieved based on spectroscopic data. These results further demonstrate the abundance of bioactive chlordane and halirnane diterpenes in the Caesalpiniaceous family, as previously reported elsewhere.en_US
dc.identifier.citationkihampa, C(2008) Mosquitocidal and antimicrobial nor-halimanoids, ent-clerodanoids and other metabolites from some Tanzanian tessmannia and annonaceae species, Doctoral dissertation, University of Dar es Salaam. Dar es Salaam.en_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/1870
dc.language.isoenen_US
dc.subjectMicrobial metabolitesen_US
dc.subjectMosquitoes controlen_US
dc.subjectLeguminosaeen_US
dc.subjectLegumesen_US
dc.subjectAnnonaceaeen_US
dc.subjectRepellentsen_US
dc.subjectBotanical chemistryen_US
dc.subjectBotanical insectisidesen_US
dc.titleMosquitocidal and antimicrobial nor-halimanoids, ent-clerodanoids and other metabolites from some Tanzanian tessmannia and annonaceae species.en_US
dc.typeThesisen_US
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