Antimicrobial, antiviral, larvicidal and other secondary metabolites from Tanzanian annonaceae species
| dc.contributor.author | Samwel, Stephen | |
| dc.date.accessioned | 2019-06-04T11:12:40Z | |
| dc.date.accessioned | 2020-01-07T15:46:33Z | |
| dc.date.available | 2019-06-04T11:12:40Z | |
| dc.date.available | 2020-01-07T15:46:33Z | |
| dc.date.issued | 2010 | |
| dc.description | Available in print form | en_US |
| dc.description.abstract | This Thesis reports the results from investigations of five Tanzanian Annonaceae species in which the leaves of Toussaintia orientalis Verdc. yielded the new indolidinoids toussaintine A - C, the N-cinnamoyl hydrobenzofuranoid toussaintine D, the N-cinnamoyl acetoxymethylcyclohexenoid toussaintine E, the β-glucoglycerylaminooctenyl adipate named orientalin, and the glycoflavonoid 3'-dehydroxyquercitrin. The leaves of another Toussaintia species, T. patriciae Q. Luke & Deroin which was only recently described, gave ursolic acid, its derivatives 19α,23-dihydroxyursolic acid and 29-hydroxyursolic acid, together with ethyl gallate. The stem and root barks of Artabotrys modestus Verdc. yielded the new diphenylpentanoid artabotrinone, aminotriketide diterpenoid artabotramide and known metabolites. The new N-methoxyoxoaporphinoid artamonteirine and the naphthalene derivative artamonterone were obtained from the stem bark of A. monteiroae Oliv. The leaves, stem and root barks of the new Annonaceae species Mwasumbia alba Couvreur & D.M. Johnson yielded the cyclitol quebrachitol, together with polycarpol. The structures of the isolated compounds were established based on analysis of their spectroscopic data, some structures also being further confirmed by X-ray diffraction analysis. Some of the isolated compounds exhibited in vitro antimicrobial potency against Staphylococcus aureus, Escherichia coli, Candida albicans and Cryptococcus neoformans, in ovo antiviral efficacy against Infectious Bursal Disease Virus and Newcastle Disease Virus, and larvicidal activity against Anopheles gambiae s.s Giles mosquito larvae. These results demonstrated some of the compounds to be potential leads for drug development. | en_US |
| dc.identifier.citation | Samwel, S (2010) Antimicrobial, antiviral, larvicidal and other secondary metabolites from Tanzanian annonaceae species. Ph.D dissertation, University of Dar es Salaam. Available at http://41.86.178.3/internetserver3.1.2/detail.aspx | en_US |
| dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/1901 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of Dar es Salaam | en_US |
| dc.subject | Annonaceae Species | en_US |
| dc.subject | Secondary metabolites | en_US |
| dc.subject | Tanzania | en_US |
| dc.title | Antimicrobial, antiviral, larvicidal and other secondary metabolites from Tanzanian annonaceae species | en_US |
| dc.type | Thesis | en_US |