Chemical investigations of the fruits of Lettowianthus Stellatus

dc.contributor.authorMtega, Sabanitho Laurent
dc.date.accessioned2020-07-23T14:45:38Z
dc.date.available2020-07-23T14:45:38Z
dc.date.issued1995
dc.descriptionAvailable in print form, East Africana Collection, Dr. Wilbert Chagula Library, Class mark ( THS CHEM QK495.A6M81)en_US
dc.description.abstractThe phytochemical investigations of fruits of L. stellatus (Annonaceae) as reported in this Dissertation have yielded four hitherto unknown compounds, namely 3,7- bis-geranyl substituted naphthoquinones (20 and 21), a bicyclo[3.3.0]-l-octen-3,8-dion-4- (3,7-diniethyl-octa-3,6-diene)-6-(2,6-dimethyl hepta-l,5-diene]-6-carboxylic methyl ester 22 and 1,4-dihydroxy-2,6-bis-geranyI substituted inden-3-one (23). All the isolated compounds were inactive in the brine shrimp test, as was the crude extract. Antimalarial and antitrypanosomal tests of the four compounds will be carried out at the Swiss Tropical Institute in Switzerland, but results from these tests will not be available for this Dissertation. The 3,7-bis-geranyl substituted naphthoquinone 21 was found to be very similar to 20. However, compound 20 has keto groups attached to C-l' and C-l" of the geranyl units, whereas 21 has enol-groups at the same positions. This suggested that 20 and 21 are biosynthetic modifications of one another. Although the MS of compound 21 did not reveal the molecular ion peak at m/z 584, other spectral data, especially NMR spectra, provided enough information which enabled elucidation of structure 21. Bicyclo [3.3.0]-1 -octen-3,8-dion-4-(3.7-dimethyl-octa-3,6-diene)-6-(2,6- dimethyl hepta-l,5-diene)-6-carboxylic methyl ester (22) was isolated from the least polar VLC fraction. Purification of 22 by using Sephadex LH-20 was difficult because the solubility of 22 in methanol was poor and only a mixture of methanol/chloroform was found to be an ideal solvent system for this purification. 1,4-Dihydroxy-2,6-bis-geranyl substituted inden-3-one (23) was isolated from the most polar VLC fraction. The purification of 23 just like that of 22 caused some difficulties owing to the lack of the suitable solvent system for purification on Sephadex LH-20. The combination of methanol/chloroform was found to be unsuitable. For this reason compound 23 could not be purified completely using the available laboratory facilities. However, the available spectral data of the impure sample were sufficient foi identification of compound 23.en_US
dc.identifier.citationMtega, S L (1995), Chemical investigations of the fruits of Lettowianthus Stellatus , Master dissertation, University of Dar es Salaam. Dar es Salaam.en_US
dc.identifier.urihttp://41.86.178.5:8080/xmlui/handle/123456789/13198
dc.language.isoenen_US
dc.publisherUniversity of Dar es Salaamen_US
dc.subjectLettowianthus stellatusen_US
dc.subjectAnalysisen_US
dc.subjectAnnonaceaeen_US
dc.subjectAntimalarialsen_US
dc.titleChemical investigations of the fruits of Lettowianthus Stellatusen_US
dc.typeThesisen_US
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