Anti-mosquito terpenoids and other constituents of selected Tanzanian plants

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Unversity of Dar es Salaam
This Telesis reports on phytochemical, repellency and larvicidal investigation of seven plants species against Anopheles gambiae mosquito. During the studies structures of seventy six essential oil constituents were identified from Uvariodendron gorgonis Verde, Clausena anisata (Wild) Benth, Steganataenia araliacea Hochst, Suregada zanzibariensis Verde and lantana viburnoides ssp. Viburnoides var.kisi (A. Rich) Verde. Most of them were- tested for mosquito repellent activity. Some essential oils and methyl ketones constituents showed good repellency activity (Chapter 2). Extracts from five plant species, namely Synadenium glaucensen Verde, Kotschya uguenensis Verde L, vibumoides, and Saraliacea were screened for larvicidal activity. Four extracts, namely dichlorometlune extract from the root balk of L viburnoides (LRRD), dichloromethane root bark extract of S. araliacea (SARD) and methanol extracts from the root (KURM) and stem barks (KUSM) of K. Uguenensis showed pronounced larvicidal and insect growth disruption properties (Chapter 3) Bioassay guided fractionation of LRRD yielded four series of inseparable mixtures of closely related furanonaphthaquinone derivatives, three triterpenoids a bis-phenyl peroxide and stigmasterol (Chapter 4). Bioassay guided fractionation of SARD yielded four bisbenzocyclooctadiene lactone lignans, two fatty acids and P-sitosterol (Chapter 5) while KURM and KUSM yielded unidentified, unstable compounds as active principles, together with a butenyl monoterpene disaccharide (kotside) (Chapter 6). Although structures of the unstable compounds could not be established because of instability, they exhibited significant bioactivity which prompted further bioassay of the extract and powdered plant materials formulations. The formulations (KURP, KUSP. KURME and KUSME) showed good results reducing mosquito larval and pupal population, with complete mortality occurring in 2-8 days Chapter 6 and 7.
Available in print form, East Africana Collection, Dr. Wilbert Chagula Library, Class mark (THS EAF QR201.M3T34 I56)
Malaria control, Vector control, Anti-mosquito, Dar es Salaam, Tanzania
Innocent, E. (2007) Anti-mosquito terpenoids and other constituents of selected Tanzanian plants, Master dissertation, University of Dar es Salaam, Dar es Salaam