Antimycobacterial, antioxidant and other secondary metabolites from heritiera littoralis and Sonneratia alba
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Date
2012
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University of Dar es salaam
Abstract
This thesis reports results of phytochemical investigations of secondary metabolites from mangrove species Heritiera littoralis Dryand and Sonneratia alba Smith. The studies aimed to establish antimycobacterial, antioxidants and other chemical constituents from two plant species so as to provide information on biomedical plant constituents and contribute to scientific knowledge. In this study, the leaves of H. littoralis yielded a new flavonoid glycoside 3''-Cinnamoyltribuloside, known flavonoid glycosides afzelin, astilbin and tribuloside as well as two pentacyclic triterpenoids 3β-Taraxerol and friedelin. The leaves of S. alba gave a hitherto unreported unusual flavonoid that was trivially named sonneratone. Structures of isolated compounds were elucidated based on spectroscopic data. The pure compounds except 3β-Taraxerol and sonneratone (the latter was not tested) exhibited in vitro antimycobacterial activity against two non-pathogenic mycobacteria species Mycobacerium madagascariense (DSM 44641) and M. indicus pranii (DSM 45239). The flavonoid glycosides exhibited high DPPH (1,1-Diphenyl-2-picrylhydrazyl) radical scavenging activities. These results demonstrate that some of compounds from investigated mangrove species are potential antimycobacterial and antioxidant leads for drug development and/or food supplement. The isolation of secondary metabolites which have proved to be of invaluable antimycobacterial and antioxidant efficacy from investigated mangrove species in this study shows that the two species are good sources of biologically active constituents, from which further studies may lead towards unraveling more interesting compounds.
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Keywords
Heritiera, Sonneratiaceae, Antimycobacterial, Antioxidants
Citation
Christopher, R (2012), Antimycobacterial, antioxidant and other secondary metabolites from heritiera littoralis and Sonneratia alba, master dissertation, University of Dar es Salaam. Available at (http://41.86.178.3/internetserver3.1.2/detail.aspx?parentpriref=)