Jaundice in Dar es Salaam diagnosis and prognosis

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University of Dar es Salaam
Jaundice or “yellow eyes” as called by the laiety, is a problem that has been recognized for many centuries. The multifactorial causes have been pnly partially elucided since the 19th century. But there re still mysteries surrounding jaundice yet to be clarified. Despite the many causes identified so far, quite a number of people rquate jaundice with viral hepatitis. In this study as attempt in made to identify the various aetiologies of jaundice as seen in the medical wards of Muhimbili Medical Centre. The study comprises of two parts, A and B. part A reviews the literature as regards the pigment billirubin, which is responsible for jaundice. Its sources are sought, metabolic pathway closely followed to is excretion. A classification of jaundice is made, and the various causes and mechanism of causation are reviewed. The possible investigations known to date are also reviewed in reasonable detail. Part B is the study. This involves patients with jaundice seen and investigated by the author. The causes of jaundice in these patients were searched for as far as possible and each patient assigned into a particular classification according to predetermined criteria. The work is concluded by a discussion on the results of the study which showed that out of 113 patients admitted into the study, 54 (47.7%) had prehapatic jaundice, 49 (43.3%) had hepatic jaundice, 7(6.2%) had prehapatic jaundice, 49 (43.3%) had hepatic jaundice, 7(6.2%) had posthepatic and 3 (2.8%) had mixed jaundice. It is found that despite lack of sophisticated investigations, most patients with jaundice can have the aetiology discovered and properly classified by a good clinical avaluation. The literature cited is listed at the end.
Available in print form, EAF Collection, Dr. Wilbert Chagula Library, (THS EAF RC851.O43)
Jaundice, Dar es Salaam (Tanzania)
Ole-King'ori, N.L (1985) Jaundice in Dar es Salaam diagnosis and prognosis, Masters dissertation, University of Dar es Salaam, Dar es Salaam